Humanoid, mortal antagonists: crime lords, financiers, warlords, cultists, chaos mages, and political schemers.
| Name | Summary |
|---|---|
| Adred Roberts | Pirate captain; brother of a heroic pirate captain. |
| Aleksandr Evil | Evil clone and cult agent of a hostile god. |
| Aleksandr | |
| Alistrix | “Goldfang” Drevarian; crime lord, a figure of fascination and fear. |
| Azernathy | Financier and schemer with an infernal pact. |
| Black Lotus | |
| Crackjaw | Loxodon gang leader, the Shatterjacks. |
| Daryon | |
| Iblis | Cult leader and warlock. |
| Inanna | Monster hunter turned villain-agent; deceased. |
| Korvec | Chaos sorcerer, Sinister Seven. |
| Loom | Shadar-Kai master schemer; leader of the Sinister Seven. |
| Lysandra Vex | Crime financier; the Brüd Crime Family’s money-launderer. |
| Misielaeam Clearsky | Eco-terrorist; incarcerated. |
| Oleracea Betandra | Criminal; incarcerated. |
| Rinaldo | Don of the Cascarani Crime Family. |
| Sun Chang | |
| Tah’Caluss Yorn | Master of the Murkwrought Marauders and the Raven Queen’s Left Hand; a Shadar-Kai warlord. |
| Tenzo Shinoda | Jiaohai-born crime lord; tournament host; central antagonist of Enter the Game of the Fist of Death. |
| Venera Drakhal | Schemer; Sinister Seven and Order of the Golden Blade double agent. |
| Zevok the Black | Ancient warrior and former hero who turned rogue after the Extinguishment. |
| Zhēnxiān Shítángláng | |
| Zidon | Schemer and pawn of Aleksandr Evil; deceased. |
| Velthur Avaini | Head of the Avaini Crime Family. |
| Ermun Sappali | Underboss in the Avaini Crime Family. |
| Smiling Jorin | Con man posing as an itinerant merchant. |
| The Maker | Off-screen, identity-unknown patron of Copper Azide II. |
| Elion | Recluse tied to a Moonblade artifact; failed his lineage. |